Journal of Biological Chemistry
Editors' PicksMtcB, a member of the MttB superfamily from the human gut acetogen Eubacterium limosum, is a cobalamin-dependent carnitine demethylase
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Author contributions—D. J. K., L. Z., and J. A. K. data curation; D. J. K., E. J. B., L. Z., and J. A. K. formal analysis; D. J. K., E. J. B., L. Z., and J. A. K. investigation; D. J. K., L. Z., and J. A. K. visualization; D. J. K., E. J. B., L. Z., and J. A. K. methodology; D. J. K. and J. A. K. writing-original draft; D. J. K., E. J. B., L. Z., and J. A. K. writing-review and editing; E. J. B., L. Z., and J. A. K. resources; L. Z. software; L. Z. and J. A. K. funding acquisition; J. A. K. conceptualization; J. A. K. supervision; J. A. K. validation; J. A. K. project administration.
Funding and additional information—This research was supported by National Institutes of Health Grant 1R01DK109345 (to J. A. K.). The Fusion Orbitrap instrument was supported by National Institutes of Health Grant S10 OD018056 (to L. Z.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
Present address for Duncan J. Kountz: Dept. of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, USA.
Abbreviations—The abbreviations used are:
- TMA
trimethylamine
- TMAO
trimethylamine N-oxide
- nonPyl
nonpyrrolysine
- THF
tetrahydrofolate
- emPAI
exponentially modified protein abundance index
- PIPE
polymerase incomplete primer extension
- OD
optical density
- MFS
major facilitator family
- CI
confidence interval.